Protein Details: Neuronal acetylcholine receptor subunit beta-2

Protein ID

ICDB_Pro_1481

Protein Name

Neuronal acetylcholine receptor subunit beta-2

Gene Name

Chrnb2

Organism

Mus musculus (Mouse)

Length

501 amino acids

AlphaFoldDB

AF-Q9ERK7-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Sequence

MARCSNSMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGTLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGRSMGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTATTFLHSDHSAPSSK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 81: "Key residue that facilitates effective access of the conotoxin BuIA to the channel binding site"; SITE 133: "Key residue for a low dissociation (K(off)) from the conotoxin BuIA"; SITE 141: "Key residue for a low dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

Predominantly expressed by immature T-cells in the thymus

DOI ID

10.1016/s0165-5728(02)00220-5

RefSeq

NP_683746.1